External Validation
HeRO User Reports Rio et al, in Switzerland, found “An increase of HRC index > 2 has a significant association with the diagnosis of [late onset sepsis (LOS)], supporting the use of HRC monitoring to assist early detection of LOS.” Kurul and colleagues, in the Netherlands, found that after implementing HeRO: Morbidity at the time of sepsis diagnosis was reduced “suggesting that patients were diagnosed earlier and less severely ill” Mortality after infection trended down (p=0.13) Antibiotic usage per 1000 NICU days trended down (p=0.06) There were more labs but no increase in blood cultures. Bennaoui et al, Marrakech University Hospital, found "The HeRO score is a useful tool for predicting the risk of infection in newborns and identifying those who may require closer monitoring or prophylactic treatment."