Trends, hard limits, and alarms have been used for years to signal that a patient is currently deteriorating. HeRO is different. HeRO identifies subtle irregularities in heart rate variability that occur hours and days prior to patient deterioration and provides an early warning of patient distress, including sepsis1,2, NEC2,3, UTI1,4, meningitis4, respiratory decompensation2,5,6, brain pathology7,8,9, and death1. And unlike any other monitoring technology available, HeRO has been proven in the most rigorous scientific fashion to improve survival 10.
Released very early in infection, cytokines are the mediators of the inflammatory response. They have effects throughout the body, including the way the pacemaker of the heart responds to the autonomic nervous system. During the early stage of infection and other inflammatory events, characteristic abnormal heart rate patterns occur that HeRO has been trained to identify, and HeRO renders a score every hour that is the risk of infection in the next 24 hours11.
There is a large body of literature demonstrating that delays in antibiotic administration can increase mortality and morbidity12,13,14,15,16. Researchers hypothesized that by improving the timing of the diagnosis, HeRO monitoring might improve outcomes for NICU patients. They conducted the largest ever randomized control trial in neonatology, where 3,003 very low birthweight babies were randomized to either receive standard of care, or standard of care plus HeRO.
For patients in the HeRO monitored group, there was at least an 18 hour average difference in the timing of the rise in HeRO score relative to the diagnosis. And if the antibiotics can be started that much earlier, the infection can be nipped in the bud—before it goes systemic, before organs start shutting down, before the really bad outcomes occur. The HeRO monitored group benefitted from a 22% reduction in mortality. For infected babies, the mortality improvement was 40%16, and their length of stay was decreased by 3.2 days17. And there was no increase in antibiotic usage for healthy babies16.
Trends and limits tell you what is happening. HeRO is an early warning system that tells you what is going to happen. HeRO…Because timing is critical.